Orthologs and Syntelogs in Pan-Genome Analysis

Orthologs are genes in different species that evolved from a common ancestral gene through speciation. They often retain similar functions and are key to comparative genomics.

Syntelogs are a special subset of orthologs identified by conserved synteny — their genomic neighborhoods contain the same flanking genes across species. This added context increases confidence in functional conservation and evolutionary relatedness.

In this database, syntelogs are used to improve gene annotation accuracy and reveal evolutionarily stable genomic regions.